Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves     

Van de Weerdt ML  Coghe J  Uystepruyst C  Deby-Dupont G  Lekeux P 《Veterinary journal (London, England : 1997)》1999,157(1):39-49

The purposes of this study were: (1) to investigate which arachidonic acid metabolites contributed to platelet-activating factor (PAF) induced pulmonary dysfunction; and (2) to compare the effect of two non-steroidal anti-inflammatory drugs, phenylbutazone and ketoprofen in a model of PAF-induced reversible lung inflammation in six calves. In placebo and phenylbutazone groups, PAF infusion induced significant dysfunctions in the pattern of breathing, mechanics of breathing and gas exchange. These dysfunctions were prevented by ketoprofen pretreatment, except for the mechanics of breathing which was moderately but significantly altered by the PAF challenge. In all calves, leukotriene (LT) B4 plasma concentrations did not significantly increase above baseline values at any time. Prostaglandin (PG) E2 plasma concentrations showed a minor significant increase in phenylbutazone pretreated calves (55.8 +/- 25.8 pg/mL from 36.7 +/- 16.13 pg/mL). Thromboxane (TX) B2 plasma concentration was significantly increased during PAF challenge in placebo- and phenylbutazone-pretreated groups, but not in ketoprofen-pretreated calves (1580.0 +/- 1370 from 42.7 +/- 10.7 pg/mL; 2340 +/- 477 from 63 +/- 32 pg/mL; and 36.5 +/- 4.12 from 39.3 +/- 12.0 pg/mL, respectively). These data suggest that TXA2 is an important cyclooxygenase metabolite of arachidonic acid produced in response to PAF and that ketoprofen (intramuscular injection, 3 mg/kg) is more effective than phenylbutazone (intramuscular injection, 10 mg/kg) in preventing respiratory dysfunctions induced by the PAF challenge 30 min after drug administration. Ketoprofen did not suppress totally the PAF-induced changes in mechanics of breathing, which suggests that PAF or a secondary release of mediators could have a direct action on airway smooth muscle.  相似文献   

Evaluation of peritoneal fluid pH, glucose concentration, and lactate dehydrogenase activity for detection of septic peritonitis in horses     

Van Hoogmoed L  Rodger LD  Spier SJ  Gardner IA  Yarbrough TB  Snyder JR 《Journal of the American Veterinary Medical Association》1999,214(7):1032-1036

OBJECTIVE: To determine whether peritoneal fluid pH, glucose concentration, and lactate dehydrogenase activity can be used to differentiate horses with septic peritonitis from those with nonseptic peritonitis. DESIGN: Prospective study. ANIMALS: 46 horses, including 10 healthy horses, 15 horses with septic peritonitis, and 21 horses with nonseptic peritonitis. PROCEDURE: Peritoneal fluid and blood samples were analyzed for pH, glucose concentration, and lactate dehydrogenase activity. Complete blood cell counts were performed, and peritoneal fluid samples were submitted for bacterial culture. RESULTS: Horses with septic peritonitis had significantly lower peritoneal fluid pH and glucose concentrations than horses with nonseptic peritonitis and healthy horses. Compared with other tests, serum-to-peritoneal fluid glucose concentration differences > 50 mg/dl had the highest diagnostic use for detection of septic peritonitis. Peritoneal fluid pH < 7.3, glucose concentration < 30 mg/dl, and fibrinogen concentration > 200 mg/dl were also highly indicative of septic peritonitis. CLINICAL IMPLICATIONS: Peritoneal fluid pH and glucose concentration can be used to assist in the identification of horses with septic peritonitis. These measurements can provide an early indication of sepsis, especially if cytologic evaluation of peritoneal fluid is unavailable or results are equivocal and peritoneal fluid bacterial culture results are pending.  相似文献   

Comparison of models to estimate genetic effects of weaning weight of Angus cattle     

Dodenhoff J  Van Vleck LD  Wilson DE 《Journal of animal science》1999,77(12):3176-3184

Weaning weights from nine sets of Angus field data from three regions of the United States were analyzed. Six animal models were used to compare two approaches to account for an environmental dam-offspring covariance and to investigate the effects of sire x herd-year interaction on the genetic parameters. Model 1 included random direct and maternal genetic, maternal permanent environmental, and residual effects. Age at weaning was a covariate. Other fixed effects were age of dam and a herd-year-management-sex combination. Possible influence of a dam's phenotype on her daughter's maternal ability was modeled by including a regression on maternal phenotype (fm) (Model 3) or by fitting grandmaternal genetic and grandmaternal permanent environmental effects (Model 5). Models 2, 4, and 6 were based on Models 1, 3, and 5, respectively, and additionally included sire x herd-year (SH) interaction effects. With Model 3, estimates of fm ranged from -.003 to .014, and (co)variance estimates were similar to those from Model 1. With Model 5, grandmaternal heritability estimates ranged from .02 to .07. Estimates of maternal heritability and direct-maternal correlation (r(am)) increased compared with Model 1. With models including SH, estimates of the fraction of phenotypic variance due to SH interaction effects were from .02 to .10. Estimates of direct and maternal heritability were smaller and estimates of r(am) were greater than with models without SH interaction effects. Likelihood values showed that SH interaction effects were more important than fm and grandmaternal effects. The comparisons of models suggest that r(am) may be biased downward if SH interaction and(or) grandmaternal effects are not included in models for weaning weight.  相似文献   

Neurotoxicity in calves induced by the plant, Nierembergia hippomanica Miers var. violacea Millán in South Africa     

Botha CJ  Schultz RA  Van Der Lugt JJ  Retief E  Labuschagne L 《The Onderstepoort journal of veterinary research》1999,66(3):237-244

The plant Nierembergia hippomanica var. violacea has been incriminated in field outbreaks of neurotoxicity in calves in the Free State Province. Hepatotoxicity and electrocardiogram (ECG) deviations were induced in a sheep dosed with 5 g/kg dried plant material on four consecutive days. A calf dosed with 2.5 g/kg dried plant material, on two consecutive days, did not show overt clinical changes. Voluntary ingestion of approximately 30 g/kg fresh flowering plants by a second calf resulted in nervous signs characterized by chewing motions, protrusion of the tongue, dysphagia, hypermetria, ataxia, paresis and lateral recumbency. Salivation, dehydration and cardiac irregularities completed the clinical picture. Clinical chemistry changes revealed muscle damage and increased serum urea and creatinine concentrations indicative of kidney involvement. This is the first confirmed outbreak of Nierembergia hippomanica var. violacea intoxication of stock in South Africa.  相似文献   

Outbreak of toxoplasmosis in wallabies on an exotic animal farm.     

M A Miller  K Ehlers  J P Dubey  K Van Steenbergh 《Journal of veterinary diagnostic investigation》1992,4(4):480-483

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Effect of benomyl on soil fungi associated with rye. 2. Effect on fungi of culm bases and roots     

G. J. Bollen  E. P. Van Der Hoeven  J. G. Lamers  M. P. M. Schoonen 《European journal of plant pathology / European Foundation for Plant Pathology》1983,89(1-2):55-66

The mycoflora of culm bases and roots of rye was assessed in field trials, where benomyl was applied at dose rates ranging from 0.24 to 4.80 kg ha^?1. Samples of culm bases were taken three times during the growing season, those of roots only at the harvest date. On culms with various symptoms from untreated plots,Pseudocercosporella herpotrichoides, Alternaria spp. andGerlachia nivalis were prevalent and on those from benomyl-treated plotsAlternaria spp. andFusarium culmorum. In later stages of growth,G. nivalis sharply declined andAlternaria spp. andF. culmorum increased. At the end of the season,Periconia macrospinosa andTyphula incarnata appeared in treated plots. In samples of roots taken more than two months after the last spray, porosporous dematiaceous species (Alternaria, Ulocladium andDendryphion), Mortierella spp. and other resistant fungi were prevalent in plots treated with 1.20 kg ha^?1 or more, but not in those that received 0.24 kg ha^?1, which is recommended for disease control. Lower counts were recorded only for species that are highly sensitive in vitro, e.g.Microdochium bolleyi andTrichoderma spp. Some fusaria were either not affected or tended to be slightly stimulated by the treatment. An attempt was made to attribute the incidence of these moderately sensitive fungi to the effect of the fungicide on non-pathogens.  相似文献   

In utero transmission of bovine leukemia virus   总被引：8，自引：0，他引：8  

M J Van der Maaten  J M Miller  M J Schmerr 《American journal of veterinary research》1981,42(6):1052-1054

In an initial study, 18 calves born to cows persistently infected with bovine leukemia virus (BLV) were tested for infective virus and antibodies at birth, and no infected or seropositive animals were found. Four of these calves were maintained in quarters where infected animals were housed, and 3 of the 4 subsequently became infected. These were probably contact infections acquired during, or at some time after, birth. The remaining 14 calves were kept in isolation pens in a building housing no infected cattle. None of this group was found to be BLV infected during 1 year of observation. In further studies, 15 pregnant cows inoculated with BLV became infected. One abortion, considered to be unrelated to the BLV inoculation, occurred 38 days later. The remaining 14 cows gave birth to 1 dead and 14 live calves. The dead calf and its live twin were seropositive for BLV at birth, indicating that they had been infected in utero. The remaining 13 calves were negative for BLV antibodies at birth and remained so during 1 year of observation.  相似文献   

Interpreting problem diarrheas of dogs   总被引：2，自引：0，他引：2  

H J Van Kruiningen  D W Hayden 《The Veterinary clinics of North America》1973,2(1):29-47

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Early embryonic death in ewes given Veratrum californicum     

K R Van Kampen  W Binns  L F James  L D Balls 《American journal of veterinary research》1969,30(4):517-519

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Tenosynovitis of the deep digital flexor tendon in horses.          下载免费PDF全文

R W Van Pelt  W F Riley  Jr    P J Tillotson 《The Canadian veterinary journal. La revue veterinaire canadienne》1969,10(9):235-243

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